We use cookies to give you the best possible experience on our site. By continuing to use the site, you agree to our use of cookies. Learn More
The Super Antioxidant in OPC-3: Pycnogenol®‡
Pycnogenol helps your skin cells maintain peak vitality.
Isotonix OPC-3® Beauty Blend contains the only isotonic form of Pycnogenol® in the world. Pycnogenol® is a plant extract from the bark of the French maritime pine tree and one of the most clinically researched and powerful bioflavonoids; its high polyphenol and antioxidant content helps promote skin health by providing a defense against skin damage and signs of aging.
Product Classification
Gluten-Free
No Detectable GMO
Vegetarian
Good Manufacturing Practices
Isotonic
Embrace Inner Beauty, Defend Your Outer Youth
Help improve and maintain the appearance of healthy, beautiful skin with some of the most powerful free radical-scavenging antioxidants known to date. They work behind the scenes to defend against damage and signs of aging. The purest and best-researched OPCs chosen for Isotonix OPC-3® Beauty Blend support your skin's ability to regenerate new epidermal cells, making beautiful skin more achievable. Our formulation aims to benefit all angles of beauty, from helping to minimize the visual appearance of fine lines and wrinkles, to working to maintain your inner youth by supporting healthy cellular renewal.
Key Ingredients & Benefits
Pycnogenol®‡, Pine Bark Extract
Maintains healthy collagen and elastin levels to help preserve the elasticity of skin
Helps support the skin’s natural defenses from harmful environmental pollutants and chemicals
Selectively binds to collagen and promotes the normal production of endothelial nitric oxide
Supports a smooth, soft and even-toned complexion
Hyaluronic Acid (as sodium hyaluronate)
Promotes healing of minor skin injuries
Supports healthy tissue hydrodynamics, movement and the production of cells
Helps maintain healthy connective tissue and supports joint health
Promotes healthy functioning of the skin at the cellular level, which results in healthy, vibrant-looking skin
Grape Seed Extract & Red Wine Extract
Helps maintain healthy cholesterol levels
Powerful antioxidants that provide skin with a defense against damage and signs of aging
Bilberry Extract
Supports healthy vision and venous circulation
Helps maintain healthy circulation by strengthening capillaries, arteries and veins
Helps maintain overall eye health
Biotin
Helps maintain healthy hair and nails
Promotes an increase in energy levels
Replenishes essential B vitamins that are important cofactors, promoting the normal metabolism of fats, carbohydrates and protein
Citrus Bioflavonoids Complex
Promotes cardiovascular health and maintains vascular integrity
Helps maintain healthy circulation and cell vitality by strengthening capillaries, arteries and veins
Promotes collagen renewal, which supports firmness of the skin, joint cartilage and connective tissue
Isotonix_Delivery_System
:05 minutes
Isotonix Liquid Vitamins
• Formulated to survive digestion.
• Delivers concentrated nutrients to the site of absorption.
• Contains no fillers or binders.
• No artificial color or flavors.
:40 minutes
Standard Vitamin Tablet
• Contains lab-created coatings and lubricants.
• Often contains artificial colors, nutrients and flavors.
• Limited absorption of nutrient utilization.
Frequently Asked Questions
What is Isotonix OPC-3 Beauty Blend? What exactly does it do?
Isotonix OPC-3 Beauty Blend is a revolutionary product that helps to do just what the name says, helps with our beauty, appearance from the inside out. It uses the most powerful free radical scavenging antioxidants known to date. The purest and best-researched OPCs chosen for Isotonix OPC-3's Beauty Blend are derived from grapes, bilberries, Pycnogenol (pine bark) and citrus-fruit. These have the highest total polyphenol content. In addition to being powerful antioxidants, these OPCs are known to promote skin health. These powerful bioflavanoids are considered many times more powerful than vitamins C and E as free radical scavengers. They do, however, work well with both vitamin C and E. Antioxidants found in Isotonix OPC-3 Beauty Blend scavenge free radicals within cells and promote optimal cellular functioning. The OPCs support your skin's natural ability to regenerate new epidermal cells, paving the way for true splendor in the way of skin beautification. Isotonix OPC-3 Beauty Blend helps to replenish the skin's vitamins and minerals. This combination of powerful OPCs is unique to Isotonix OPC-3’s OPC-3 Beauty Blend as is the Isotonix delivery system, which enables rapid and highly efficient absorption of OPC's, vitamins and minerals.
Who should take Isotonix OPC-3 Beauty Blend? Do OPCs contain benefits specific to women?
Anyone and everyone! We are constantly in environments that can be quite stressful on the delicate nature of our skin. Everyone should take precautions against the effects of stress, aging and the environment when it comes to maintaining skin health. In clinical trials, some OPCs were shown to help women who suffer from mild pain and cramping during menstruation. When women were supplemented with OPCs starting at least a week before their menstrual period, pain values were found to be significantly lowered. Men may also benefit from taking this product, as it is formulated for anyone interested in maintaining healthy, youthful-looking skin and performing their best.*
I am healthy and athletic; why should I take Isotonix OPC-3 Beauty Blend?
While everyone is vulnerable to the aging process caused by continuous free radical damage, athletes tend to be exposed to elevated levels of oxidative stress. Free radicals develop as byproducts during metabolism when calories are processed with oxygen. Athletes inhale 10 to 20 times more oxygen during physical activity over rest periods. The increase in activity creates additional free radicals, which are known to limit performance, as free radicals can take their toll on muscle tissue. Studies on recreational athletes have shown a 20% increase in endurance with OPCs compared to a control group receiving a placebo. Another study has shown that athletes using OPCs suffered significantly less muscle cramping during and after performing. Isotonix OPC-3 Beauty Blend helps maintain healthy blood flow, supporting oxygen supply to muscles.*
Does OPC-3 have visible benefits or rejuvenating effects?
As OPCs support collagen production in the skin, an increase in smoothness and support of elasticity are the natural results. It requires patience until skin cells have renewed significant amounts of collagen to show visible effects. Such an effect was objectively measured in women aged 40 years and older, in which skin smoothness increased after three months as measured by three-dimensional topography. It is essential to continuously take OPC-3 to maintain skin cell health.* On a short-term basis, many people notice a fresher-looking complexion; this is a result of healthy blood microcirculation, which helps detoxify the skin and support the nutrient supply. The damage caused by free radicals adds up over time. A cause for more worry is the fact that your body's own mechanisms to keep free radicals in check decline with increasing age, when you need them the most. Suddenly, we find ourselves confronted with some typical age-related problems. Some of the body’s cells are more vulnerable to free radicals than others. OPC-3 has the ability to go in and do a knockout job, cleaning and scavenging the free radicals that feast on cellular energy and take it away from vital processes.*
What are bioflavonoids? What sets Isotonix OPC-3 Beauty Blend apart from other bioflavonoid products?
Bioflavonoids are complex organic plant compounds. An increasing number of clinical studies have shown how bioflavonoids support health. Bioflavonoids found in OPCs play a key role in cardiovascular health and maintaining vascular integrity; they have been shown to demonstrate their support for healthy circulation and cell vitality. Normal collagen renewal is promoted, which supports firmness of the skin, joint cartilage and connective tissue. Isotonix OPC-3 offers scientifically supported OPCs, found to be one of the most powerful antioxidants for human health, including grape seed, red wine, bilberries and Pycnogenol®. In addition to being powerful antioxidants, these individual OPCs have been shown to provide a myriad of specific health benefits. The Isotonix delivery system is unique to OPC-3, which enables rapid and highly efficient absorption of the OPCs. The powerful nutrients, in combination with the highly effective delivery system, make OPC-3 the most powerful free radical-scavenging product available.*
Research Scope
Science
Bayeta, E., et al. Pycnogenol inhibits generation of inflammatory mediators in macrophages. Nutrition Research 20: 249-259, 2000.
Blazsó, G., et al. Anti-inflammatory and superoxide radical scavenging activities of a procyanidins containing extract from the bark of Pinus pinaster Sol. and its fractions. Pharm Pharmacol Lett 3: 217-20, 1994.
Block, A., and Bettelheim, F. Water Vapor Sorption of Hyaluronic Acid. Biochim Biophys Acta 201:69, 1970.
Chen, W., et al. Functions of hyaluronan in wound repair. Wound Repair Regen. 7:79-89, 1999.
Cho, K., et al. Effect of bioflavonoids extracted from the bark of Pinus maritima on proinflammatory cytokine interlukin-1 production in lipopolysaccharide-stimulated RAW 264. 7. Toxicology and Applied Pharmacology 168: 64-71, 2000.
Cho, K., et al. Inhibition mechanisms of bioflavonoids extracted from the bark of Pinus maritima on the expression of proinflammatory cytokines. Annals of the NY Academy of Sciences 928: 141-156, 2001.
Devaraj, S., et al. Supplementation with a pine bark extract rich in polyphenols increases plasma antioxidant capacity and alters the plasma lipoprotein profile. Lipids 37:931-4, 2002.
Fine, AM, Oligomeric proanthocyanidin complexes: history, structure, and phytopharmaceutical applications. Altern Med Rev 5:144-51, 2000.
Fitzpatrick, D., et al. Endothelium-dependent vascular effects of Pycnogenol. Journal of Cardiovascular Pharmacology 32: 509-515, 1998.
Frankel, E., et al. Inhibition of oxidation of human low-density lipoprotein by phenolic substances in red wine. Lancet 341: 454-7, 1993.
Freedman, J., et al. Select flavonoids and whole juice from purple grapes inhibit platelet function and enhance nitric oxide release. Circulation 103:2792-8, 2001.
Frémont, L. Biological effects of resveratrol. Life Sciences 66: 663-673, 2000.
Ghersetich, I., et al. Hyaluronic acid in cutaneous intrinsic aging. International Journal of Dermatology. 33(2):119-122, 1994.
Gulati, O. Pycnogenol® in venous disorders: a review. European Bulletin of Drug Research 7: 1-13, 1999.
Hosseini, S., et al. Pycnogenol® in the management of asthma. Journal of Medicinal Food 4: 201-209, 2001.
Kohama, T., et al. The treatment of gynecological disorders with Pycnogenol®. European Bulletin of Drug Research 7: 30-32, 1999.
Kohama, T., et al. Analgesic efficacy of French maritime pine bark extract in dysmenorrhea. Journal of Reproductive Medicine 49: 828-32, 2004.
Liu, X., et al. Antidiabetic effect of Pycnogenol French maritime pine bark extract in patients with diabetes type II. Life Sci 75:2505-13, 2004.
Liu, X., et al. French maritime pine bark extract pycnogenol dose-dependently lowers glucose in type 2 diabetic patients. Diabetes Care 27: 839, 2004.
MacKay, N., et al. Nutritional support for wound healing. Alternative Medicine Review. 8: 359-77, 2003.
Manna, S., et al. Resveratrol suppresses TNF-Induced activation of nuclear transcription factors NF-kB, activator protein-1, and apoptosis: potential role of reactive oxygen intermediates and lipid peroxidation. The Journal of Immunology 164: 6509-19, 2000.
Maritim, A., et al. Effects of pycnogenol treatment on oxidative stress in streptozotocin-induced diabetic rats. J Biochem Mol Toxicol 17:193-9, 2003.
Meyer, L., et al. Age-dependent changes of hyaluronan in human skin. J Invest Dermatol. 102:385-9, 1994.
Miyagi, Y., et al. Inhibition of human low-density lipoprotein oxidation by flavonoids in red wine and grape juice. Am J Cardiol 0:1627-31, 1997.
Monograph. Vaccinium myrtillus (bilberry). Altern Med Rev 6:500-4, 2001.
Murias M., et al. Resveratrol analogues as selective cyclooxygenase-2 inhibitors: synthesis and structure-activity relationship. Bioorg Med Chem 12: 5571-8, 2004.
Nachbar, F., et al. The role of vitamin E in normal and damaged skin. J Mol Med. 73(1):7-17, 1995.
Nuttall SL, Kendall MJ, Bombardelli E, Morazzoni P. An evaluation of the antioxidant activity of a standardized grape seed extract, Leucoselect. J Clin Pharm Ther 23: 385-89, 1998.
Packer, L., et al. Antioxidant activity and biologic properties of a procyanidin-rich extract from pine (Pinus maritima) bark, pycnogenol. Free Radic Biol Med 27:704-24, 1999. Review.
Price, R., et al. The role of hyaluronic acid in wound healing: assessment of clinical evidence. Am J Clin Dermatol. 6:393-402, 2005.
Rohdewald, P. A review of the French maritime pine bark extract (Pycnogenol®), a herbal medication with a diverse clinical pharmacology. Int J Clin Pharmacol Ther 40:158-68, 2002. Review.
Rohdewald, P. Pycnogenol®. In “Flavonoids in Health and Disease”. Ed. Catherine Rice-Evans and Lester Packer. New York: Marcel Dekker, Inc., 1998. 405-19.
Roseff, S., et al. Improvement in sperm quality and function with French maritime pine tree bark extract. Journal Reproductive Medicine 47: 821-4, 2002.
Roseff, S., et al. Improvement of sperm quality by Pycnogenol®. European Bulletin of Drug Research 7: 33-6, 1999.
Saito, M., et al. Antiulcer activity of grape seed extract and procyanidins. J Agric Food Chem 46: 1460-4, 1998.
Schönlau, F., et al. Pycnogenol® for diabetic retinopathy. International Ophthalmology 24: 161-171, 2002.
Schönlau, F., et al. The cosmeceutical Pycnogenol®. J Appl Cosmetology 20: 241-6, 2002.
Segger, D. and Schönlau, F. Supplementation with Evelle® improves skin smoothness and elasticity in a double blind, placebo-controlled study with 62 women. Journal of Dermatological Treatment 15:222-26, 2004.
Shi, J., et al. Polyphenolics in grape seeds-biochemistry and functionality. J Med Food 6:291-9, 2003. Review.
Sharma, S., et al. Pycnogenol® inhibits the release of histamine from mast cells. Phytotherapy Research 17: 66-69, 2003.
Spadea, L., et al. Treatment of vascular retinopathies with Pycnogenol®. Phytotherapy Research 15: 219-23, 2001.
Takada, Y., et al. Nonsteroidal anti-inflammatory agents differ in their ability to suppress NF-kappaB activation, inhibition of expression of cyclooxygenase-2 and cyclin D1, and abrogation of tumor cell proliferation. Oncogene 23: 9247-58, 2004.
Ueda, T., et al. Preventative effect of natural and synthetic antioxidants on lipid peroxidation in the mammalian eye. Ophthalmic Res 28: 184-92, 1996.
Wallerath, T., et al. Resveratrol, a polyphenolic phytoalexin present in red wine, enhances expression and activity of endothelial nitric oxide synthase. Circulation 106:1652-8, 2002.
Watson, R. Pycnogenol® and cardiovascular health. Evidence-Based Integrative Medicine 1: 27-32, 2003.
Wei, Z., et al. Pycnogenol enhances endothelial cell antioxidant defense. Redox Report 3: 219-24, 1997.
Weindl, G., et al. Hyaluronic acid in the treatment and prevention of skin diseases: molecular biological, pharmaceutical and clinical aspects. Skin Pharmacol Physiol. 17(5):207-213, 2004.
Yamakoshi, J., et al. Proanthocyanidin-rich extract from grape seeds attenuates the development of aortic atherosclerosis in cholesterol-fed rabbits. Atherosclerosis 142:139-149, 1999.
Ames, BN, et al. Oxidants, antioxidants, and the degenerative diseases of aging. Proc Natl Acad Sci USA 90:7915-7922, 1993.
Bagchi, D, et al. Oxygen free radical scavenging abilities of vitamins C and E, and a grape seed proanthocyanidin extract in vitro. Res Commun Mol Pathol Pharmacol 95:179-89, 1997.
Bagchi, D, et al. Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention. Toxicology 148: 187-97, 2000.
Bagchi, D, et al. Cellular protection with proanthocyanidins derived from grape seed. Ann NY Acad Sci 957:260-70, 2002.
Graham DY, Smith JL, Bouvet, AA. What happens to tablets in the stomach. J Pharm Sci 79:420-24, 1990.
Havsteen B. Flavonoids, a class of natural products of high pharmacological potency. Biochem Pharm 32:1141-48, 1983.
Halpern, MJ, et al. Red wine polyphenols and inhibition of platelet aggregation: possible mechanisms, and potential use in health promotion and disease prevention. J Int Med Res 26:171-80, 1998.
Kehrer JP. Free radicals as mediators of tissue injury and disease. Crit Rev Toxicol 23:21-48, 1993.
Koch R. Comparative study of Venostatin and Pycnogenol in chronic venous insufficiency. Phytother Res 16:S1-5, 2002.
Koparker AD, Augsburger LL, Shangraw RF. Intrinsic dissolution rates of tablet fillers and binders and their influence on the dissolution of drugs from tablet formulations. Pharm Res 7:80-85, 1990.
Cesarone MR et al. Improvement in circulation and in cardiovascular risk factors with a proprietary isotonic bioflavonoid formula OPC-3. Angiology. 59(4):408-14, 2008.
Cesarone MR et al. Accelerated antioxidant bioavailability of OPC-3 bioflavonoids administered as isotonic solution. Phytotherapy Research. 23(6):775-7, 2009.
Rohdewald, P. A review of the French maritime pine bark extract (Pycnogenol), a herbal medication with a diverse clinical pharmacology. International Journal of Clinical Pharmacology and Therapeutics. 40(4):158-168, 2002.
Barringer T et al. Potential Benefits on Impairment of Endothelial Function after a High-fat Meal of 4 weeks of Flavonoid Supplementation. Evidence-based Complementary and Alternative Medicine: eCAM. doi:10.1093/ecam/nen048: 1-6, 2008.
Reviews
Customer Rating
4.8 out of 5 star rating.
(34 reviews)
would recommend this product.
- Newest
- Highest Rating
- Lowest Rating
- Oldest
- Most Helpful
My wife and I have always been great fans of all Market America's product lines. Isotonix specfic is the best of them all.
Response from Customer Service on 05/04/2026
Thank you so much for your fantastic review of Isotonix OPC-3® Beauty Blend! We’re thrilled to hear that you and your wife are such loyal fans of Market America’s product lines. Your enthusiasm for Isotonix means a lot to us, and we truly appreciate your continued support. Thank you for being a part of our community and sharing your positive experience!
LOVE LOVE LOVE!!!
by JUDIM
Shop Consultant
on 09/04/2024
This product is the foundation that I build my healthy lifestyle on!!
Response from Customer Service on 09/05/2024
Thank you for your enthusiastic review! We're thrilled to hear that our product plays such a crucial role in your healthy lifestyle. Your passion and satisfaction mean a lot to us!
我女儿每天都用,让皮肤更漂亮
by JINGHUAL
Shop Consultant
on 11/24/2020
我女儿每天都用,让皮肤更漂亮
Response from Customer Service on 11/24/2020
尊敬的客户,
感谢您抽出宝贵的时间分享对Isotonix OPC-3 Beauty Blend的想法!我们很高兴听到您对产品感到满意。
再次感谢你!
产品信息团队
Dear Valued Customer,
Thank you for taking the time to share your thoughts on the Isotonix OPC-3 Beauty Blend! We are happy to hear you are pleased with the product.
Thank you again!
The Product Information Team
Love the Beauty Blend
by VictorC
Shop Consultant
on 09/04/2020
I was born with oily skin, even had acme growing up, even since i took beauty blend the oil on the face was controlled. I couldn't believe it . so I put it the test and not take it for two days and my oily skin came back with a pimple. I learned my lesson to take it daily now. :)
Response from Customer Service on 09/06/2020
Dear Valued Customer,
Thank you for taking the time to share your thoughts on the Isotonix OPC-3 Beauty Blend! We are happy to hear you are pleased with the product.
Thank you again!
The Product Information Team
Love my OPC Beauty Blend
by Anonymous
on 08/02/2020
my nails are strong and healthy by using this product and my hair is getting thicker as well
Response from Customer Service on 08/03/2020
Dear Valued Customer,
Thank you for taking the time to share your thoughts on the Isotonix OPC-3 Beauty Blend! We are happy to hear you are pleased with the product.
Thank you again!
The Product Information Team
Share this page!
Copy this link and paste to your favorite social, blog or website.
Link copied! Please paste and share on your favorite platforms.
There was an error copying to your clipboard. Please try again later.