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A Mighty Molecule
70%
boost in body antioxidant levels with curcumin supplementation
50%
more active enzymes than other brands

Bromelain
Comes from a mixture of enzymes found in the stems of pineapples. As a mixture of protease, bromelain has been used by Europeans for many years to promote optimal cell health and the normal healing process.

Product Classification

Gluten-Free

Vegan

Non-GMO

Isotonic
Key Ingredients & Benefits

Protease
supports the body's normal healing process
supports a healthy immune system
promotes healthy joint function

Bromelain
Help normal healing process
Promotes optimal cell health
Isotonix Delivery System

:05 minutes
Isotonix Liquid Vitamins
- Formulated to survive digestion.
- Delivers concentrated nutrients to the site of absorption.
- Contains no fillers or binders.
- No artificial color or flavors.

:40 minutes
Standard Vitamin Tablet
- Contains lab-created coatings and lubricants.
- Often contains artificial colors, nutrients and flavors.
- Limited absorption of nutrient utilization.
Frequently Asked Questions
Who should take Isotonix™ Bromelain Plus?
Isotonix Bromelain Plus is formulated for everyone, every day. Its unique combination of benefits — supporting the body’s normal ability to repair itself, promoting the body’s normal processes — make it ideally suited for adults looking to keep their bodies healthy and to help support the body’s ability to deal with the wear and tear of everyday life.
What sets Isotonix Bromelain Plus apart from other products?
Proteolytic enzyme potency can be denoted by using various activity units like FCC Papain units (PU), Gelatin Digestion Units (GDU), or Bromelain Tyrosine Units (BTU). Regardless of how the label reads, make sure when comparing products, that the units are the same so that you are comparing correctly what the actual “concentration” or “activity” of the enzyme is being used in the product. It is not enough to simply look at how much (milligrams or grams) of an enzyme is in a serving. To accurately compare how much active bromelain enzyme is in a serving, always refer to the GDU or PU units. Our Bromelain Plus contains 0.544 grams of bromelain, which is equal to 1296 GDUs or 19,440,000 FCC PU per daily serving. Bromelain Plus is not only isotonic, but it also contains another protease enzyme, which provides for even greater activity and a more potent, effective product.
Where does bromelain come from?
Bromelain is found in every part of the pineapple, although it is most plentiful in the stem. Most commercially-grown pineapple is sliced, canned or juiced. The remains are rich with this substance, which is then extracted. Originally used as a meat tenderizer because of its ability to break down proteins, research now shows that powdered bromelain promotes health.
Scientific Studies
- Akhtar NM, Naseer R, Farooqi AZ, Aziz W, Nazir M. Oral enzyme combination versus diclofenac in the treatment of osteoarthritis of the knee--a double-blind prospective randomized study. Clin Rheumatol. 2004 Oct;23(5):410-5. Epub 2004 Jul 24.
- Batkin S, Taussig SJ, Szekerezes J. Antimetastatic effect of bromelain with or without its proteolytic and anticoagulant activity. J Cancer Res Clin Oncol 1988;114:507.
- Bhattacharyya Barun. Bromelain: An Overview. Natural Product Radiance. 7(4):359-63, 2008.
- Blonstein JL. Control of swelling in boxing injuries. Practitioner 1960; 185:78.
- Brien S, Lewith G, Walker A, Hicks SM, Middleton D. Bromelain as a Treatment for Osteoarthritis: a Review of Clinical Studies. Evid Based Complement Alternat Med. Dec;1(3):251-257, 2004.
- Bromelain Monograph. Alternative Medicine Review. 15: 361-368, 2010.
- Chobotova K, Vernallis AB, Majid FA. Bromelain's activity and potential as an anti-cancer agent: Current evidence and perspectives. Cancer Lett. 28;290(2):148-56, 2010.
- Cirelli M. Treatment of inflammation and edema with bromelain. A plant proteolytic enzyme concentrate. Del Med J. 1962 Jun;34:159-67, 1962.
- Desser L, Rehberger A, Paukovits W. Proteolytic enzymes and amylase induce cytokine production in human peripheral blood mononuclear cells in vitro. Cancer Biother 1994;9:253-263.
- Desser L, Rehberger A. Induction of tumor necrosis factor in human peripheral-blood mononuclear cells by proteolytic enzymes. Oncology 1990;47:475-477.
- Desser L, Rehberger A, Kokron E, et al. Cytokine synthesis in human peripheral blood mononuclear cells after oral administration of polyenzyme preparations. Oncology 1993;50:403-407.
- Gläser D, Hilberg T. The influence of bromelain on platelet count and platelet activity in vitro. Platelets. 2006 Feb;17(1):37-41.
- Hale LP, Greer PK, Sempowski GD. Bromelain treatment alters leukocyte expression of cell surface molecules involved in cellular adhesion and activation. Clin Immunol 2002;104:183-90.
- Heinicke RM, Van der Wal M, Yokoyama MM. Effect of bromelain on human platelet aggregation. Experientia 1972;28:844-845.
- Kamenícek V, Holán P, Fran?k P. Systemic enzyme therapy in the treatment and prevention of post-traumatic and postoperative swelling. Acta Chir Orthop Traumatol Cech. 2001;68(1):45-9.
- Kerkhoffs GM, Struijs PA, de Wit C, Rahlfs VW, Zwipp H, van Dijk CN. A double blind, randomised, parallel group study on the efficacy and safety of treating acute lateral ankle sprain with oral hydrolytic enzymes. Br J Sports Med. 2004 Aug; 38(4):431–435.
- Klein G, Kullich W, Schnitker J, Schwann H. Efficacy and tolerance of an oral enzyme combination in painful osteoarthritis of the hip. A double-blind, randomised study comparing oral enzymes with non-steroidal anti-inflammatory drugs. Clin Exp Rheumatol. 24(1):25-30, 2006.
- Masson M. Bromelain in blunt injuries of the locomotor system. A study of observed applications in general practice. Fortschr Med 1995;113:303-306.
- Morita AH, Uchida DA, Taussig SJ. Chromatographic fractionation and characterization of the active platelet aggregation inhibitory factor from bromelain. Arch Inter Phar Ther 1979;239:340-350.
- Müller S, März R, Schmolz M, Drewelow B, Eschmann K, Meiser P. Placebo-controlled randomized clinical trial on the immunomodulating activities of low- and high-dose bromelain after oral administration - new evidence on the antiinflammatory mode of action of bromelain. Phytother Res. 27(2):199-204, 2013.
- Nieper HA. Effect of bromelain on coronary heart disease and angina pectoris. Acta Med Empirica 1978;5:274-278.
- Nieper HA. Decrease of the incidence of coronary heart infarct by Mg- and K-orotate and bromelain. Acta Med Empirica 1977;12:614-618.
- Nouza K. Physical activity and immune system. Systemic enzyme therapy in prevention and treatment. Medicina Sportiva Boh Slov. 1997; 6(2):41–45.?
- Rajendra Pavan, Sapna Jain, Shraddha, Ajay Kumar. Properties and Therapeutic Application of Bromelain: A Review. Biotechnol Res Int. 1-6, 2012 .
- Seligman B. Oral bromelain as adjuncts in the treatment of acute thrombophlebitis. Angiology 1969;20:22-26.
- Singer F., Singer C., Oberleitner H. Phlogenzym® versus Diclofenac in the treatment of activated osteoarthritis of the knee. A double-blind prospective randomized study. Int. J. Immunotherapy. 17: 135-14, 2001.
- Tassman GC, Zafran JN, Zayon GM. Evaluation of a plant proteolytic enzyme for the control of inflammation and pain. J Dent Med 1964;19:73-77.
- Tassman GC, Zafran JN, Zayon GM. A double-blind crossover study of a plant proteolytic enzyme in oral surgery. J Dent Med 1965;20:51-54.
- Taussig SJ, Batkin S. Bromelain, the enzyme complex of pineapple (Ananas comosus) and its clinical application. An update. J Ethnopharmacol 1988;22:191-203.
- Taussig SJ, Szekerczes J, Batkin S. Inhibition of tumor growth in vitro by bromelain, an extract of the pineapple plant (Ananas comosus). Planta Med 1985;6:538-539.
- Tilwe GH, Beria S, Turakhia NH, Daftary GV, Schiess W. Efficacy and tolerability of oral enzyme therapy as compared to diclofenac in active osteoarthrosis of knee joint: an open randomized controlled clinical trial. J Assoc Physicians India. 49:617-21, 2001.
- Vellini M, Desideri D, Milanese A, et al. Possible involvement of eicosanoids in the pharmacological action of bromelain. Arzneimittelforschung 1986;36:110-112.
- Walker AF, Bundy R, Hicks SM, Middleton RW. Bromelain reduces mild acute knee pain and improves well-being in a dose-dependent fashion in an open study of otherwise healthy adults. Phytomedicine. 2002 Jan 1;9(8):681-6.
Reviews
Customer Rating
4.5 out of 5 star rating.
(24 reviews)
would recommend this product.
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- Most Helpful
I like its taste and aroma very much, and it works very well, especially in the cold season, it can play beyond my imagination.
Response from Customer Service on 03/30/2023
Dear Valued Customer,
Thank you for taking the time to share your thoughts on the Isotonix Bromelain Plus! We are so happy to hear you are pleased with the product!
Thank you again!
The Product Information Team
Bromelain
by Anonymous
on 07/10/2022
This product works as expected. It balanaces out my lack of proper nutrician,
Response from Customer Service on 07/11/2022
Dear Valued Customer,
Thank you for taking the time to share your thoughts on the Isotonix® Bromelain Plus! We are so happy to hear you are pleased with the product!
Thank you again!
The Product Information Team
Best sleep ever!
by HANNAHF
on 06/22/2022
I've been taking the Bromelain with digestive enzymes and opc3 as a bedtime cocktail. Not only am I getting a deeper more restful night sleep but I'm waking up easier and more energized.
Response from Customer Service on 06/22/2022
Dear Valued Customer,
Thank you for taking the time to share your thoughts on the Isotonix® Bromelain Plus! We are so happy to hear you are pleased with the product!
Thank you again!
The Product Information Team
Shoppers found this review helpful
They send me the wrong product
by SarahB
on 05/29/2021
They sent me something else and are not answering the email I sent to the support team.
Response from Customer Service on 06/02/2021
Dear Valued Customer,
Thank you for contacting Market America|Shop.com. We do apologize that you received the wrong product. One of our customer service experts will reach out and assist you in resolving this matter.
If you would like to call us directly, please feel free to contact us at 1-866-420-1709 Monday-Friday between the hours of 9:00 a.m.-9:00 p.m. EST.
I haven’t received it yet
by Anonymous
on 09/29/2020
I haven’t received it yetI would love to give a review however it’s been over two weeks since I ordered and I have not received the product.
Response from Customer Service on 09/30/2020
Dear Valued Customer,
Thank you for contacting Market America|Shop.com. We sincerely apologize for the inconvenience in not receiving the order. We are working to resolve the issue as quickly as possible.
One of our customer service experts will reach out to you and gather further details.
If you would like to call us directly, please feel free to contact us at 1-866-420-1709 Monday-Friday between the hours of 9:00 a.m.-9:00 p.m. EST.
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